Table 1.

Incidence of cardiovascular death, myocardial infarction or ischaemic stroke and stent thrombosis by CYP2C19 genotype comprising 9685 patients

	Hazard ratio	95% confidence interval	P value
Cardiovascular death, myocardial infarction or ischaemic stroke
Carriers of one or two CYP2C19 alleles with reduced function vs. non-carriers	1.57	1.13, 2.16	0.006
Carriers of one CYP2C19 allele with reduced function vs. non-carriers	1.55	1.11, 2.17	0.01
Carriers of two CYP2C19 alleles with reduced function vs. non-carriers	1.76	1.24, 2.50	0.002
Stent thrombosis
Carriers of one or two CYP2C19 alleles with reduced function vs. non-carriers	2.81	1.81, 4.37	<0.00001
Carriers of one CYP2C19 allele with reduced function vs. non-carriers	2.67	1.69, 4.22	<0.0001
Carriers of two CYP2C19 alleles with reduced function vs. non-carriers	3.97	1.75, 9.02	0.001

Determined CYP2C19 alleles with reduced function: CYP2C19^*2, CYP2C19^*3, CYP2C19^*4, CYP2C19^*5 and CYP2C19^*8. Data adopted from Mega et al., 2010 42.