Fig. 1.

Subtypes of cortical pTDP-43 pathology in FTLD. pTDP-43 IHC shows pTDP-43 pathology in the anterior cingulate gyrus thatp resented either with predominantly perikaryal pTDP-43 inclusions (cytoplasmic type in a, c, e) or with long and extensive aggregates in dendrites (neuritic type in b, d, f). Both the neuritic type and the cytoplasmict ype showed prominent involvement of projection neurons of cortical layers II and III (c, d), although the cytoplasmic type more often showed involvement of Betz pyramidal cells of layer Vb in the primary motor cortex than the neuritic type. Scale in a applies to b; scale bar in c is also valid for d–f