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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Pharmacogenomics J. 2012 Jun 12;13(4):362–368. doi: 10.1038/tpj.2012.21

Figure 5.

Figure 5

αC418W mice display a higher percentage of Cav-1 positive end-plates, which is in turn reduced by statin treatment. Tibialis anterior muscle cryo-sections were obtained from αC418W and WT mice. These were stained for nAChRs, Cav-1 and nuclei with α-bungarotoxin, immunohistochemistry using anti-Cav-1 antibodies and DAPI, respectively. (a) αC418W mice showed a significant amount of Cav-1 colocalizing with end-plates, as identified by nAChR staining, whereas WT mice displayed a significant lower amount (**P<0.01, n=3 for αC418W and WT mice on PBS treatment) (scale bars represent 36μm). (b) After 36 days of treatment, αC418W mice showed a significant reduction in the percentage of Cav-1-positive end-plates, whereas the WT percentages remained unchanged (*P<0.05, n=3 for αC418W and WT mice on PBS and statin treatment).