TABLE 1.
Autoantibody findings in PANDAS
Reference | Method | Clinical syndrome (number of patients) | Finding |
---|---|---|---|
70 | IF | PANDAS (N = 22) vs. uncomplicated Strep. infection (n = 22) | Positive binding in 64% vs. 9% |
71 | ELISA | PANDAS (n = 15) vs. control (n = 15) | No difference in patients compared to controls |
72 | ELISA | PANDAS (n = 40) vs. controls (n = 190) | Elevated mean ELISA in PANDAS vs. controls |
69 | ELISA | PANDAS (n = 48) vs. TS (N = 46) vs. control (n = 43) | No difference in patients compared to controls |
72 | WB | PANDAS (n = 40) vs. controls (n = 190) | Positive binding in 92% vs. 5% |
71 | WB | PANDAS (n = 15) vs. controls (n = 15) | No difference in binding between groups |
69 | WB | PANDAS (n = 48) vs. controls (n = 43) | No difference in binding between groups |
73 | Cell surf. | PANDAS (n = 16) vs. TS, OCD, ADHD (n = 25) | Positive binding to cell surface in PANDAS more than TS, OCD, ADHD |
IF, immunofluorescence; ELISA, enzyme linked immunosorbent assay; WB, Western blotting; Cell surf, cell surface binding to live neurons; PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection; TS, Tourette syndrome; OCD, obsessive-compulsive disorder; ADHD, attention deficit hyperactivity disorder.