Table 3.

Inflammatory Array Analysis Uncovers Differences in Inflammation with Aging and MMP-28 Deletion.

	WT		MMP-28−/−
Genes	Young (n = 3)	Old (n = 3)	Young (n = 9)	Old (n = 7)
Abcf1a	0.163 ± 0.001	0.152 ± 0.007	0.248 ± 0.009*§	0.229 ± 0.019†
C3a	0.174 ± 0.009	0.309 ± 0.035*	0.114 ± 0.013	0.236 ± 0.027*
Ccl3a	0.0010 ± 0.0001	0.0009 ± 0.0002	0.0007 ± 0.0002	0.0023 ± 0.0005*†
Ccl8b	0.009 ± 0.001	0.047 ± 0.019	0.009 ± 0.002	0.054 ± 0.019*
Ccl11a	0.008 ± 0.001	0.011 ± 0.002	0.010 ± 0.001	0.017 ± 0.002*†
Ccl25b	0.0024 ± 0.0002	0.0020 ± 0.0002	0.0034 ± 0.0006	0.0049 ± 0.0013†
Ccr7b	0.00017 ± 0.00002	0.00019 ± 0.00003	0.00225 ± 0.00106*§	0.00335 ± 0.00221
Cx3cl1a	0.0347 ± 0.0024	0.0289 ± 0.0032	0.0395 ± 0.0033	0.0587 ± 0.0068*†
Cxcl13b	0.0018 ± 0.0002	0.0060 ± 0.0024	0.0017 ± 0.0008	0.0069 ± 0.0027*
Il10rba	0.284 ± 0.024	0.317 ± 0.015	0.424 ± 0.020*§	0.364 ± 0.034
Il13ra1a	0.079 ± 0.008	0.096 ± 0.004	0.065 ± 0.004	0.065 ± 0.007†
Itgama	0.014 ± 0.001	0.020 ± 0.002	0.009 ± 0.001	0.012 ± 0.002†
Mifa	0.370 ± 0.007	0.337 ± 0.006	0.919 ± 0.068*§	0.909 ± 0.098†
Scye1a	0.311 ± 0.022	0.277 ± 0.008	0.428 ± 0.019*§	0.426 ± 0.031†
Tnfrsf1aa	0.033 ± 0.001	0.031 ± 0.002	0.046 ± 0.004	0.055 ± 0.006†
Tollipa	0.076 ± 0.005	0.069 ± 0.005	0.114 ± 0.007*§	0.092 ± 0.009

Of 84 genes analyzed, the 16 genes shown were statistically different among the groups. Gene levels are reported as 2^−ΔCT units. Ccl3 = macrophage inflammatory protein-1α. All values are mean ± SEM.

^*p < 0.05 versus respective young control;

^§p < 0.05 versus WT young;

^†p < 0.05 versus WT old.

^aAnalyzed by ANOVA.

^bAnalyzed by Kruskal-Wallis test.