Table 4.

Extracellular Matrix and Adhesion Molecule Array Analysis Uncovers ECM Differences with Aging and MMP-28 Deletion.

	WT		MMP-28−/−
Genes	Young (n = 3)	Old (n = 3)	Young (n = 9)	Old (n = 7)
Ctnna1a	1.07 ± 0.10	0.97 ± 0.03	1.58 ± 0.11*§	1.41 ± 0.06†
Ctnnb1a	0.62 ± 0.04	0.60 ± 0.02	0.46 ± 0.02*§	0.40 ± 0.02†
Cdh4b	0.008 ± 0.0004	0.012 ± 0.0005	0.003 ± 0.0004*§	0.006 ± 0.0007
Col1a1a	0.156 ± 0.003	0.095 ± 0.007*	0.044 ± 0.003*§	0.042 ± 0.005†
Col3a1a	0.88 ± 0.05	0.47 ± 0.07*	0.44 ± 0.03*§	0.40 ± 0.04
Col4a1a	0.535 ± 0.051	0.335 ± 0.003*	0.626 ± 0.046	0.568 ± 0.044†
Col6a1a	0.124 ± 0.012	0.084 ± 0.004*	0.139 ± 0.006	0.139 ± 0.007†
Vcana	0.051 ± 0.004	0.043 ± 0.004	0.012 ± 0.001*§	0.016 ± 0.002†
Fn1a	0.058 ± 0.004	0.051 ± 0.007	0.029 ± 0.003*§	0.028 ± 0.002†
Itgavb	0.089 ± 0.006	0.089 ± 0.002	0.046 ± 0.005*§	0.050 ± 0.004
Itgb1a	0.86 ± 0.08	0.94 ± 0.04	0.63 ± 0.04*§	0.62 ± 0.04†
Lama2a	0.086 ± 0.010	0.078 ± 0.009	0.115 ± 0.006	0.113 ± 0.007†
Lamb2a	0.26 ± 0.02	0.22 ± 0.02	0.52 ± 0.04*§	0.41 ± 0.03*†
Mmp9b	0.00176 ± 0.00006	0.00262 ± 0.00060	0.00214 ± 0.00041	0.00746 ± 0.00119*†
Mmp11b	0.00036 ± 0.00003	0.00043 ± 0.0008	0.00177 ± 0.00053§	0.00107 ± 0.00011
Mmp15a	0.164 ± 0.002	0.146 ± 0.014	0.101 ± 0.010*§	0.086 ± 0.006†
Postna	0.056 ± 0.003	0.074 ± 0.001*	0.015 ± 0.001*§	0.022 ± 0.002*†
Seleb	0.0090 ± 0.0008	0.0084 ± 0.0011	0.0033 ± 0.0005*§	0.0061 ± 0.0024
Sparca	0.597 ± 0.007	0.391 ± 0.013*	0.342 ± 0.016*§	0.360 ± 0.008
Spp1b	0.0117 ± 0.0013	0.0055 ± 0.0018	0.0018 ± 0.0008*§	0.0037 ± 0.0019
Thbs2a	0.068 ± 0.007	0.075 ± 0.003	0.048 ± 0.004*§	0.056 ± 0.004†
Timp1b	0.000054 ± 0.000004	0.000047 ± 0.000001	0.000314 ± 0.000204	0.000503 ± 0.000370†
Vtna	0.138 ± 0.004	0.117 ± 0.014	0.118 ± 0.009	0.083 ± 0.007*†

Of 84 genes analyzed, the 16 genes shown were statistically different among the groups. Gene levels are reported as 2^−ΔCT units. All values are mean ± SEM.

^*p < 0.05 versus respective young control;

^§p < 0.05 versus WT young;

^†p < 0.05 versus WT old.

^aAnalyzed by ANOVA.

^bAnalyzed by Kruskal-Wallis test.