Table 1.
Matrix metalloproteinase (MMP) expression following myocardial infarction
| MMP number |
Other names | Level post- MI |
Animal Model |
Measured in humans |
Method | References |
|---|---|---|---|---|---|---|
| MMP-1 | Collagenase 1 | LVI: ↑ Plasma: ↑ |
rat, mice | yes | immunoblot ELISA |
28,132, 133 134 |
| MMP-2 | Gelatinase A | LVI: ↑ Plasma: ↑ |
rat, mice | yes | immunoblot, ELISA |
28, 132, 133 135 |
| MMP-3 | Stromelysin 1 | LVI: ↑ | rabbit | no | zymography | 41 |
| MMP-7 | Matrilysin | LVI: ↑ | mice | no | immunoblot | 14 |
| MMP-8 | Neutrophil collagenase; collagenase 2 |
LVI: ↑ | rat sheep |
no | immunoblot |
45
46 |
| MMP-9 | Gelatinase B | LVI: ↑ Plasma: ↑ |
rat, mice, dog, rabbit, |
yes | immunoblot, ELISA |
28, 132, 133 47, 135-137 |
| MMP-10 | Stromelysin 2 | Plasma: = | yes | ELISA | 138 | |
| MMP-11 | Stromelysin 3 | Unknown | ||||
| MMP-12 | Macrophage elastase |
Unknown | ||||
| MMP-13 | Collagenase 3 | LVI: ↑ | sheep | no | immunoblot | 46 |
| MMP-14 | Membrane type (M↑)1- MMP |
LVI: ↑ | rat sheep |
no | immunoblot |
16
46 |
| MMP-15 | MT2-MMP | Unknown | no | |||
| MMP-16 | MT3-MMP | Unknown | no | |||
| MMP-23 | CA-MMP | Unknown | no | |||
| MMP-26 | Matrilysin-2 | Unknown | no | |||
| MMP-27 | Unknown | no | ||||
| Myocyte- derived MMP-28 |
Epilysin | LVI: ↓ | mice | no | immunoblot | 19 |
| Macrophage -derived MMP-28 |
LVI: ↑ | mice | no | immunoblot |
LVI- left ventricle infarct region; CA-MMP – Cysteine Array Matrix Metalloproteinase