Table 3.

Effect of matrix metalloproteinase (MMP) modulation on cardiac remodeling

Intervention	Model	Time post- MI effect observed	Effect	References
Broad spectrum MMP Inhibitor (CP-471,474)	mice	4 days	↓ LV dilation	81
Broad spectrum MMP Inhibitor (PD166793)	pig	5 days	↓ MI size and expansion	82
MMP Inhibitor (PGE- 530742)	pig	10 days	↓ LV end diastolic volume	53
Broad spectrum MMP Inhibitor (CP-471,474)	rabbit	4 weeks	↓ LV dilation, ↑ neovascularization	139
TISAM	mice	3 days	↑ survival, ↓ rupture	86
MMP-2 null	mice	28 days	↓ LV rupture	100
MMP-1 Tg	Mice	No additional injury	↑ systolic dysfunction, severe LV remodeling	102
MMP-2 Tg	mice	No additional injury	↑ systolic dysfunction, severe LV remodeling	103, 104
MMP-7 null	mice	7 days	↑ survival, preserved myocardial conduction patterns	111
MMP-9 null	mice	Up to 15 days	↓ LV enlargement, Collagen accumulation	101
Macrophage specific MMP-9 Tg	mice	5 days	↑ LV function, ↓inflammation	2, 105
MMP-28 null	mice	Up to 28 days	↑ LV dysfunction and rupture	15
MT1-MMP Tg	mice	Up to 14 days	↑ LV remodeling, fibrosis, ↓ survival	46
TIMP-1 null	mice	Up to 14 days	↑ LV remodeling	48
TIMP-2 null	mice	1 week	↑ Infarct expansion, LV dysfunction and inflammation	107
TIMP-3 null	mice	5 and 30 days	↑ LV rupture	140
TIMP-4 null	mice	3-7 days	↑LV rupture	109

I/R - ischemia/ reperfusion; LV- left ventricle; M – myocardial infarction; Tg- transgenic; TISAM –((2R)-2-[5-[4-[ethyl-methylamino]phenyl]thiophene-2-sulfonylamino]-3-methylbutyric acid