Table 2.

Experimental design of injected mouse cohorts.

Mouse Line	N	Age	Dox	Antibody	Injection sites	Time between injection and sacrifice
Line 107	4	6	+	5 μg 7B6	2	7 days
Line 107	4	6	+	5 μg IB3	2	7 days
Line 107	4	6	+	5 μg 6E10	2	7 days
Line 85	6	15	+	5 μg 6E10	2	7 days
Line 85	5	12	−	2 μg 6E10	1	3 days
Line 85	3	12	−	2 μg bio-6E10	1	24 h
Line 85	3	12	−	2 μg bio-6E10	1	3 days

Line 107 or Line 85 mice received intracerebral injections of Aβ antibodies in the presence or absence of doxycycline chow (Dox) which suppresses amyloid precursor protein expression in Line 107 mice, and were sacrificed 3 or 7 days after injection. Age is given in months. Bio-6E10 refers to the biotinylated form of the 6E10 antibody.