Table 3.
Cox proportional hazards models of predictors of time to spontaneous HCV clearance among participants with acute HCV infection.
| Model | Adjusted HR¥ (95% CI) | P | |
|---|---|---|---|
| 1 | Age, sex/IL28B genotype and HCV genotype¥ | ||
| Sex and IL28B genotype | |||
| Male, CT/TT | 1.00 | - | |
| Male, CC | 1.81 (1.06, 3.10) | 0.029 | |
| Female, CT/TT | 1.64 (0.87, 3.08) | 0.129 | |
| Female, CC | 4.65 (2.71, 7.96) | <0.001 | |
| HCV genotype 1 (vs. genotype non-1) | 1.53 (1.04, 2.27) | 0.031 | |
| 2 | Age, sex/HCV genotype and IL28B genotype¥ | ||
| Sex and HCV genotype | |||
| Male, genotype non-1 | 1.00 | - | |
| Male, genotype 1 | 1.40 (0.82, 2.37) | 0.217 | |
| Female, genotype non-1 | 1.87 (0.99, 3.54) | 0.053 | |
| Female, genotype 1 | 3.30 (1.94, 5.62) | <0.001 | |
| IL28B CC genotype (vs. CT/TT) | 2.23 (1.50, 3.30) | <0.001 | |
| 3 | Age, HCV genotype/IL28B genotype and sex¥ | ||
| HCV genotype and IL28B genotype | |||
| Genotype non-1, CT/TT | 1.00 | - | |
| Genotype non-1, CC | 3.82 (1.86, 7.84) | <0.001 | |
| Genotype 1, CT/TT | 2.66 (1.30, 5.47) | 0.008 | |
| Genotype 1, CC | 4.56 (2.28, 9.12) | <0.001 | |
| Female sex (vs. male sex) | 2.23 (1.52, 3.28) | <0.001 | |
| 4 | Females: Age, IL28B genotype and HCV genotype┼ | ||
| IL28B CC genotype (vs. CT/TT) | 2.89 (1.60, 5.22) | <0.001 | |
| HCV genotype 1 (vs. genotype non-1) | 1.78 (1.00, 3.17) | 0.052 | |
| 5 | Males: Age, IL28B genotype and HCV genotype‡ | ||
| IL28B CC genotype (vs. CT/TT) | 1.79 (1.05, 3.06) | 0.033 | |
| HCV genotype 1 (vs. genotype non-1) | 1.40 (0.82, 2.38) | 0.220 | |
| 6 | IL28B CT/TT genotype: Age, sex and HCV genotypeα | ||
| Female sex (vs. male sex) | 1.74 (0.92, 3.30) | 0.089 | |
| HCV genotype 1 (vs. genotype non-1) | 2.65 (1.29, 5.46) | 0.008 | |
| 7 | IL28B CC genotype: Age, sex and HCV genotypeβ | ||
| Female sex (vs. male sex) | 2.64 (1.62, 4.31) | <0.001 | |
| HCV genotype 1 (vs. genotype non-1) | 1.18 (0.74, 1.90) | 0.488 | |
All models adjusted for age, Tests for interaction on the multiplicative scale: Model 1: P = 0.265; Model 2: P = 0.560; Model 3: P = 0.068.
¥
includes 448 participants in the final adjusted model,
┼
includes 151 participants in the final adjusted model,
‡
includes 297 participants in the final adjusted model,
α
includes 227 participants in the final adjusted model,
β
includes 221 participants in the final adjusted model.