Table 2.
Frequency of GERD symptoms |
BE cases, n (%) |
Primary-care controls, n (%) |
ORb (95% CI) | |
---|---|---|---|---|
Ever | ||||
No | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
Yes | 195 (82.6) | 206 (46.1) | 5.70 | (3.86, 8.42) |
At age 10–19 years | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥1 time per month | 7 (3.0) | 0 (0.0) | — | — |
1 time per week | 5 (2.1) | 0 (0.0) | — | — |
>1 time per week | 10 (4.2) | 3 (0.7) | 20.3 | (5.28, 78.0) |
No symptomsc | 173 (73.3) | 203 (45.4) | 5.14 | (3.47, 7.61) |
At age 20–29 years | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥1 time per month | 9 (3.8) | 8 (1.8) | 7.07 | (2.53, 19.8) |
1 time per week | 12 (5.1) | 8 (1.8) | 8.32 | (3.19, 21.7) |
>1 time per week | 30 (12.7) | 9 (2.0) | 20.7 | (9.03, 47.3) |
No symptomsc | 144 (61.0) | 181 (40.5) | 4.79 | (3.20, 7.16) |
At age 30–49 years | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥1 time per month | 18 (7.6) | 34 (7.6) | 3.29 | (1.69, 6.42) |
1 time per week | 25 (10.6) | 26 (5.8) | 6.17 | (3.20, 11.9) |
> 1 time per week | 94 (39.8) | 59 (13.2) | 10.4 | (6.38, 16.8) |
No symptomsc | 58 (24.6) | 87 (19.5) | 3.85 | (2.39, 6.18) |
At age 50–79 years | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥1 time per month | 20 (8.5) | 49 (11.0) | 2.41 | (1.30, 4.48) |
1 time per week | 29 (12.3) | 37 (8.3) | 4.79 | (2.64, 8.71) |
>1 time per week | 109 (46.2) | 94 (21.0) | 7.14 | (4.60, 11.1) |
No symptomsc | 37 (15.7) | 26 (5.8) | 8.82 | (4.66, 16.7) |
10 years before diagnosis | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥1 time per month | 19 (8.0) | 46 (10.3) | 2.43 | (1.29, 4.57) |
1 time per week | 30 (12.7) | 33 (7.4) | 5.54 | (3.03, 10.1) |
>1 time per week | 122 (51.7) | 100 (22.4) | 7.50 | (4.87, 11.6) |
No symptomsc | 24 (10.2) | 27 (6.0) | 5.44 | (2.83, 10.4) |
Frequency of GERD and age at onset | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
≥Weekly age <30 years | 45 (19.1) | 18 (4.0) | 15.1 | (7.91, 28.8) |
≥Weekly age 30–49 years | 74 (31.4) | 69 (15.4) | 6.87 | (4.22, 11.2) |
≥Weekly age 50–79 years | 58 (24.6) | 72 (16.1) | 4.73 | (2.91, 7.67) |
<Weekly age <30 years | 5 (2.1) | 6 (1.3) | 5.17 | (1.48, 18.1) |
<Weekly age 30–49 years | 6 (2.5) | 21 (4.7) | 1.73 | (0.65, 4.58) |
<Weekly age 50–79 years | 7 (3.0) | 20 (4.5) | 2.04 | (0.80, 5.18) |
BE, Barrett’s esophagus; CI, confidence interval; GERD, gastroesophageal reflux disease; OR, odds ratio.
Highest reported symptoms of either heartburn or acid regurgitation.
Adjusted for age, sex, highest level of education, cumulative smoking history, body mass index, alcohol intake, and use of aspirin or nonsteroidal anti-inflammatory drugs.
Symptoms were present at other age intervals.