Table 3.
Multivariate analyses of the association between severity of pain from GERDa and BE
| Severity of pain from GERD | BE cases, n (%) | Primary-care controls, n (%) | ORb (95% CI) | |
|---|---|---|---|---|
| Ever | ||||
| Never symptoms | 41 (17.5) | 241 (53.9) | 1.00 | (Ref) |
| Mild | 29 (12.3) | 67 (15.0) | 2.43 | (1.40, 4.22) |
| Moderate | 71 (30.2) | 89 (19.9) | 5.09 | (3.20, 8.11) |
| Severe | 94 (40.0) | 50 (11.2) | 12.0 | (7.34, 19.6) |
| At age 10–19 years | ||||
| Never symptoms | 41 (29.1) | 241 (63.2) | 1.00 | (Ref) |
| Mild | 10 (7.1) | 0 (0.0) | — | — |
| Moderate | 9 (6.4) | 3 (0.8) | 17.3 | (4.44, 67.7) |
| Severe | 4 (2.8) | 0 (0.0) | — | — |
| No symptomsc | 77 (54.6) | 137 (36.0) | 3.32 | (2.14, 5.16) |
| At age 20–29 years | ||||
| Never symptoms | 41 (25.0) | 241 (61.3) | 1.00 | (Ref) |
| Mild | 21 (12.8) | 11 (2.8) | 11.2 | (4.95, 25.2) |
| Moderate | 23 (14.0) | 11 (2.8) | 12.9 | (5.78, 28.8) |
| Severe | 8 (4.9) | 3 (0.8) | 16.0 | (4.02, 64.1) |
| No symptomsc | 71 (43.3) | 127 (32.3) | 3.33 | (2.14, 5.20) |
| At age 30–49 years | ||||
| Never symptoms | 41 (19.2) | 241 (56.6) | 1.00 | (Ref) |
| Mild | 29 (13.6) | 51 (12.0) | 3.42 | (1.93, 6.05) |
| Moderate | 57 (26.8) | 44 (10.3) | 8.90 | (5.17, 15.3) |
| Severe | 50 (23.5) | 23 (5.4) | 13.3 | (7.19, 24.5) |
| No symptomsc | 36 (16.9) | 67 (15.7) | 3.05 | (1.80, 5.19) |
| At age 50–79 years | ||||
| Never symptoms | 41 (18.1) | 241 (54.8) | 1.00 | (Ref) |
| Mild | 29 (12.8) | 61 (13.9) | 2.58 | (1.47, 4.52) |
| Moderate | 58 (25.5) | 84 (19.1) | 4.36 | (2.70, 7.06) |
| Severe | 70 (30.8) | 33 (7.5) | 13.6 | (7.89, 23.6) |
| No symptomsc | 29 (12.8) | 21 (4.8) | 9.44 | (4.65, 19.2) |
| Severity of pain from GERD and age at onset | ||||
| Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
| Severe GERD < 30 years | 8 (3.4) | 3 (0.7) | 15.9 | (3.99, 63.3) |
| Severe GERD 30–49 years | 44 (18.7) | 21 (4.7) | 13.2 | (6.97, 24.9) |
| Severe GERD 50–79 years | 42 (17.9) | 26 (5.8) | 10.6 | (5.77, 19.5) |
| Less-severe GERD < 30 years | 25 (10.6) | 20 (4.5) | 7.94 | (3.98, 15.8) |
| Less-severe GERD 30–49 years | 45 (19.2) | 65 (14.5) | 4.52 | (2.68, 7.61) |
| Less-severe GERD 50–79 years | 30 (12.8) | 71 (15.9) | 2.35 | (1.36, 4.07) |
BE, Barrett’s esophagus; CI, confidence interval; GERD, gastroesophageal reflux disease; OR, odds ratio.
a
Highest severity of pain from either heartburn or acid regurgitation.
b
Adjusted for age, sex, highest level of education, cumulative smoking history, body mass index, alcohol intake, and use of aspirin or nonsteroidal anti-inflammatory drugs.
c
Symptoms were present at other age intervals.