Table 3.
Severity of pain from GERD | BE cases, n (%) | Primary-care controls, n (%) | ORb (95% CI) | |
---|---|---|---|---|
Ever | ||||
Never symptoms | 41 (17.5) | 241 (53.9) | 1.00 | (Ref) |
Mild | 29 (12.3) | 67 (15.0) | 2.43 | (1.40, 4.22) |
Moderate | 71 (30.2) | 89 (19.9) | 5.09 | (3.20, 8.11) |
Severe | 94 (40.0) | 50 (11.2) | 12.0 | (7.34, 19.6) |
At age 10–19 years | ||||
Never symptoms | 41 (29.1) | 241 (63.2) | 1.00 | (Ref) |
Mild | 10 (7.1) | 0 (0.0) | — | — |
Moderate | 9 (6.4) | 3 (0.8) | 17.3 | (4.44, 67.7) |
Severe | 4 (2.8) | 0 (0.0) | — | — |
No symptomsc | 77 (54.6) | 137 (36.0) | 3.32 | (2.14, 5.16) |
At age 20–29 years | ||||
Never symptoms | 41 (25.0) | 241 (61.3) | 1.00 | (Ref) |
Mild | 21 (12.8) | 11 (2.8) | 11.2 | (4.95, 25.2) |
Moderate | 23 (14.0) | 11 (2.8) | 12.9 | (5.78, 28.8) |
Severe | 8 (4.9) | 3 (0.8) | 16.0 | (4.02, 64.1) |
No symptomsc | 71 (43.3) | 127 (32.3) | 3.33 | (2.14, 5.20) |
At age 30–49 years | ||||
Never symptoms | 41 (19.2) | 241 (56.6) | 1.00 | (Ref) |
Mild | 29 (13.6) | 51 (12.0) | 3.42 | (1.93, 6.05) |
Moderate | 57 (26.8) | 44 (10.3) | 8.90 | (5.17, 15.3) |
Severe | 50 (23.5) | 23 (5.4) | 13.3 | (7.19, 24.5) |
No symptomsc | 36 (16.9) | 67 (15.7) | 3.05 | (1.80, 5.19) |
At age 50–79 years | ||||
Never symptoms | 41 (18.1) | 241 (54.8) | 1.00 | (Ref) |
Mild | 29 (12.8) | 61 (13.9) | 2.58 | (1.47, 4.52) |
Moderate | 58 (25.5) | 84 (19.1) | 4.36 | (2.70, 7.06) |
Severe | 70 (30.8) | 33 (7.5) | 13.6 | (7.89, 23.6) |
No symptomsc | 29 (12.8) | 21 (4.8) | 9.44 | (4.65, 19.2) |
Severity of pain from GERD and age at onset | ||||
Never symptoms | 41 (17.4) | 241 (53.9) | 1.00 | (Ref) |
Severe GERD < 30 years | 8 (3.4) | 3 (0.7) | 15.9 | (3.99, 63.3) |
Severe GERD 30–49 years | 44 (18.7) | 21 (4.7) | 13.2 | (6.97, 24.9) |
Severe GERD 50–79 years | 42 (17.9) | 26 (5.8) | 10.6 | (5.77, 19.5) |
Less-severe GERD < 30 years | 25 (10.6) | 20 (4.5) | 7.94 | (3.98, 15.8) |
Less-severe GERD 30–49 years | 45 (19.2) | 65 (14.5) | 4.52 | (2.68, 7.61) |
Less-severe GERD 50–79 years | 30 (12.8) | 71 (15.9) | 2.35 | (1.36, 4.07) |
BE, Barrett’s esophagus; CI, confidence interval; GERD, gastroesophageal reflux disease; OR, odds ratio.
Highest severity of pain from either heartburn or acid regurgitation.
Adjusted for age, sex, highest level of education, cumulative smoking history, body mass index, alcohol intake, and use of aspirin or nonsteroidal anti-inflammatory drugs.
Symptoms were present at other age intervals.