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Gadolinium-nanoshells (Gd-NS) demonstrated no toxicity in vitro with (top row) HepG2 cells and (bottom row) human dermal fibroblasts (HDF’s) at (left column) 24 h and (right column) 48 h up to 15,000 particles/cell, as determined by an MTS cytotoxicity assay. Cell viability levels were statistically equivalent among the tested concentrations of Gd-NS and PEG-nanoshells (PEG-NS) by ANOVA. Error bars represent standard deviation (n = 3).
