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Subcutaneous B16-F10 melanoma tumors in mice showed positive contrast enhancement with T1-MRI and X-ray after an intratumoral injection of gadolinium-nanoshells (Gd-NS, 50 μl at 6.3 × 1012 particles/ml). (A and B) Contrast was confined to the tumor volume compared to (C and D) tumor tissue without nanoshells. Red circles denote tumors along the right flank.
