Figure 8. Differences in fiber organization between ducts and acini formed within 5% Matrigel at day 5.

(A) The directional variance gradient of the collagen fibers is correlated with the form factor of the epithelial structure. (B) A significantly greater directional variance gradient surrounds ducts compared to acini. (C) Representative maps of directional variance indicate substantial variability surrounding ducts. (D) Fiber density gradient is also correlated with form factor. (E) Ducts have a greater fiber density gradient than acini. Data are represented as mean +/− SD. (F) Representative maps of fiber density surrounding the structures demonstrate a greater fiber density gradient during duct formation compared to acini.