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. 2014 Apr 1;9(4):e93751. doi: 10.1371/journal.pone.0093751

Figure 4. Tripartite regulatory network for Group 1 miRs.

Figure 4

This network represents the molecular cross talk between TFs, miRs and mRNAs in PD. Square nodes in the middle layer represent miRs, diamond nodes in the upper layer representing validated TFs of respective miRs and circular nodes in the lower most layer represent mRNA targets of the miRs. Here regulation goes down from TFs to miRs and then miRs to mRNAs. TFs regulate the transcription of miRs whereas miRs regulate the translation process of target mRNAs. miRs with highest intermediate regulatory measure were denoted as IR hubs. The 5 IR hub miRs in the middle layer have been enlarged for proper visualization. 29 already known PD related miRs, associated with the top 20 most significant GO Biological Processes, were used to build this network. This network was constructed in Cytoscape interface [26].