Table 4. Differences between WT DEN and Matn2-/- DEN group compared to WT DEN.
Total protein | Phosphorylation | Immunostaining | Localization | |
EGFR | - | ↓ | - | - |
Erk1/2 | ↓ | ↑ | = | cytoplasm, nucleus |
GSK-3α/β | ↓ | ↑↑ | ↓ | cytoplasm |
β-Catenin | ↓ | - | ↑ | cytoplasm |
c-Myc | - | ↓ | - | cytoplasm, nucleus |
p21/CIP1 | ↓↓ | - | ↓ | nucleus |
Ki-67 | - | - | ↑↑ | nucleus |
Rb | - | ↓ = | ↑ | nucleus |