Figure 4. Clodrolip decreases the number of collagen-producing cells and the mRNA expression of the fibroblast markers vimentin and P4hb in BCC-bearing skin of Ptch^flox/floxERT2^+/− mice.

(A) Percentage of Ki67⁺ BCC cells in liposome- or clodrolip-treated Ptch^flox/floxERT2^+/− mice. (B) TUNEL⁺ BCC cells per mm BCC-bearing skin in liposome- or clodrolip-treated Ptch^flox/floxERT2^+/− mice. (C) Collagen-producing cells (mainly fibroblast) as estimated by Goldner staining (left panel; see main manuscript for detailed informations) and qRT-PCR analysis of vimentin (middle panel) and of P4hb (right panel) in BCC-bearing skin of Ptch^flox/floxERT2^+/− mice treated with liposomes or clodrolip. Data shows the mean value (+SEM). * P<0.05, ** P<0.01, *** P<0.001.