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. 2014 Apr 1;9(4):e93207. doi: 10.1371/journal.pone.0093207

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© 2014 Hohmann et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A Temporary progression of the lobule size in dependence of , which is the sensitivity of the proliferation response to deviations from the normal shear stress value . B Temporary progression of the lobule size in the simulation with (red curve in A) in the scenarios (pHx), (STP) and (PVL) as given in Table 1. The shear stress strength is illustrated by a color-code for the different scenarios. The time point at which compensatory growth is 90% completed is marked with . C Spatial distribution of proliferation events for the scenario (pHx). For each time point, the hepatocyte layer is equally divided into three sections displayed on the horizontal axis. The proliferation events are recorded for each section over the entire simulation time and are depicted as number of proliferation events for different relative spatial positions. D The frequency of proliferation events for scenario (pHx) is depicted as number of proliferation events per time point.

Inline graphic — A Temporary progression of the lobule size in dependence of , which is the sensitivity of the proliferation response to deviations from the normal shear stress value . B Temporary progression of the lobule size in the simulation with (red curve in A) in the scenarios (pHx), (STP) and (PVL) as given in Table 1. The shear stress strength is illustrated by a color-code for the different scenarios. The time point at which compensatory growth is 90% completed is marked with . C Spatial distribution of proliferation events for the scenario (pHx). For each time point, the hepatocyte layer is equally divided into three sections displayed on the horizontal axis. The proliferation events are recorded for each section over the entire simulation time and are depicted as number of proliferation events for different relative spatial positions. D The frequency of proliferation events for scenario (pHx) is depicted as number of proliferation events per time point.