Figure 6. Snail beta subunit (LCavβ) splice isoforms containing either N-terminal exons 1a/1b or exon 2 (A or B) or insert in exon 7 (7a− vs 7a+), slow the inactivation kinetics of LCa_v2 channels.

Four representative and normalized peak barium current traces shown as mean, s.e.m. for (A) LCa_v1 and (B) LCa_v2 channels co-expressed with LCavβ splice isoforms or no Cavβ. (C) Rate of inactivation decay reflected in the fraction of maximal peak current at 250 ms time point. All LCavβ splice isoforms like vertebrate Cavβ_2a slow inactivation kinetics of LCa_v2 channels. The slowing of inactivation kinetics is maximized with the exon 7a− configuration.