Table 1. Summary of different physiological parameters analyzed in old Polμ−/− mice.
| Liver | BM | Heart | Other organs | Global | MEFs | Other | |
| Cell Cycle | x 2(a) | ||||||
| Apoptosis | x 0.1 | ||||||
| Senescence | ++ (b) | ||||||
| Mitochondrial Activity | +/− | x 1.6 (Br) | |||||
| Autophagy | +/− | +/− | +/− (Br) | ||||
| 8-oxoG bypass | +/− | x 0.2 (Br) | |||||
| Genetic stability | + (c) | x 0.7(d) | x 0.3(d) | ||||
| MSI | +/− | ||||||
| Telomere Lenght | − | − | +/− | ||||
| DSB repair | |||||||
| 53BP1 foci | x 2 | ||||||
| γ-H2AX foci | x 1.7 | > x 2 | x5 (Thy); +/− (Sp) | ||||
| Radiation sensitivity | x 2.5(e) | > x 4.5 | x 4(f) | ||||
| 8-oxoG bypass | +/− | x 0.2 (Br) | |||||
| Aging | |||||||
| Histology | − | − (Sk, Ov, Panc) | |||||
| Immunity | + (CD4/CD8; PB) | ||||||
| Biochemistry | |||||||
| Colesterol | − | ||||||
| Triglycerides | − | ||||||
| Liver function | +/− (g) | ||||||
| Glucose | − | ||||||
| Glucose tolerance | +/− | ||||||
| IGF1, GH | +/− | ||||||
| P-Hepatect. Recovery(h) | + | ||||||
| Heart function | +/− | ||||||
| ROS | +/− (i); ++ (j) | − | − (Thy); +/− (Sp) | + (k) | |||
| Paraquat Resistence (l) | + | ||||||
| HR/NHEJ | |||||||
| HR (SCE) | +/− | +/− (B cells) | + | + (m) | |||
| HR expression (n) | + | + | |||||
| Tumor susceptibility(o) | +/− (Thy) | +/− | |||||
| Life span | +/; +/− (p) |
Numbers indicates the ratio KO/WT for each parameter. Footnotes.
Corresponding specifically to G2/M cells;
Evaluation of senescence ex vivo, at atmospheric concentration of O2;
Ploidy (≥4n) evaluation after PI staining;
Aneuploidy and translocation frequency evaluation;
Evaluated on CFU-GM progenitors;
Evaluated in cell lines;
ALT/GPT; AST/GOT; Billirubin and Albumin;
P-Hepatect. Recovery: partial hepatectomy recovery;
Protein carbonyls;
peroxided lipids;
Values obtained at atmospheric oxygen;
Paraquat Resistance, (70 mg/kg; ip);
Analysis of CHO-DN cell line, at atmospheric oxygen;
HR express. qRT-PCR analysis of selected functions involved in HR;
Tumor susceptibility. Evaluation of spontaneous tumor incidence and susceptibility to thymic lymphomas by low dose of radiation;
Evaluations in 129/BALBc and B6 backgrounds, respectively; Abbreviations: Thy, thymus; Sp, spleen; Br, brain, Sk, skin; Ov, ovary; Panc, Pancreas; PB, peripheral blood. Symbols; (++), (+), (+/−) and (−) indicates that values for KO animals were clearly higher, superior, similar and reduced, respectivelly, in comparison with control (wt) animals.