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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cancer Res. 2008 Mar 15;68(6):1953–1961. doi: 10.1158/0008-5472.CAN-07-5659

Figure 1.

Figure 1

(A) Differential sensitivity of colon cancer cell lines to 72 h cetuximab treatment. Shown for simplicity are the 3 most sensitive and resistant cell lines of the 22 cell lines screened for cetuximab response. Values shown are the mean ± SEM of n=3–5 experiments. (B) Differential sensitivity of colon cancer cells to cetuximab in vivo. 5×106 cells of the cetuximab sensitive (GEO) and resistant (LIM2405) colon cancer cell lines were injected in SCID mice. Once palpable tumors had formed animals were injected with cetuximab (10 mg/kg) or PBS (control), biweekly, for 2 weeks following which animals were sacrificed, tumors excised and tumor volume calculated as in Materials and Methods.