Figure 3. Bacterial load after intratracheal instillation of Sm in C57BL/6 and Cftr mutant mice.
A) Bacterial count in the lungs of C57BL/6 mice after infection with Sm1 nebulized (2 h before infection and 1 h post-infection) with 1×PBS (n = 13), COL (n = 12) and EGCg (n = 11). Mice nebulized with EGCg exhibited significantly lower bacterial count (P = 0.0127) in comparison to non-treated group (1×PBS). Shown are mean ± SD and the distribution of the values. B) Bacterial count in the lungs of Cftr mutant mice after infection with Sm1 nebulized (2 h before infection and 1 h post-infection) with aqua (n = 10) and EGCg (n = 10). Mice nebulized with EGCg exhibited significantly lower bacterial count (P = 0.0039) in comparison to the non-treated group (aqua). Displayed are means ±SD and individual values. Aqua = sterile distilled water.