Table 1. Dose Escalation Study Selected Physiological Values.
Baseline | Post-Shock | |||
---|---|---|---|---|
Vehicle (n=9) | VPA (n=27) | Vehicle (n=9) | VPA (n=27) | |
Weight (g) | 296.55 ± 15.43 | 275.21 ± 5.66 | - | - |
MAP (mmHg) | 97.88 ± 2.29 | 95.71 ± 1.67 | 47.66 ± 4.01 | 54.11 ± 1.43 |
pH | 7.44 ± 0.01 | 7.43 ± 0.01 | 7.36 ± 0.02 | 7.38 ± 0.01 |
LAC (mmol/L) | 0.81 ± 0.10 | 0.85 ± 0.10 | 5.33 ± 0.40 | 4.19 ± 0.30 |
Data presented as group means ± SEM. VPA= valproic acid; MAP=mean arterial pressure; LAC=serum lactate