Table 2. Univariate and Multivariate Cox Hazards Analysis in the 83 GBM Patients.

Covariate	Univariate			Multivariate
	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Age	1.028	1.013–1.042	<0.001	0.990	0.971–1.010	0.344
Sex	0.812	0.516–1.277	0.368	1.384	0.843–2.273	0.199
KPS	0.957	0.935–0.980	<0.001	0.971	0.944–0.999	0.044
Tumor size	0.997	0.989–1.006	0.539	1.005	0.996–1.015	0.265
Extent of resection	1.602	1.201–2.136	0.001	1.656	1.226–2.238	0.001
MGMT	0.455	0.276–0.750	0.002	0.570	0.335–0.969	0.038
Plasma IGFBP-2	1.032	1.024–1.040	<0.001	1.035	1.024–1.047	<0.001

*KPS: Karnofsky performance status; IGFBP-2: Insulin-like growth factor binding protein 2;

MGMT: MGMT promoter methylation status.