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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Cyst Fibros. 2013 Oct 31;13(3):251–259. doi: 10.1016/j.jcf.2013.10.009

Figure 1.

Figure 1

Genotype-specific myogenic tone. Aortic segments from 7 piglets (2 WT, 3 CFTR-null, 2 CFTR-F508del) were incubated at 1, 2, 4, 6 or 8g-force resting tension and myogenic tone was assessed (A, symbol size is proportionate to resting tension). Aortic segments from additional WT (open symbols, N=38), null (black symbols, N=29), and dF piglets (gray symbols, N=11) were incubated at 2g resting tension for 3 hours and the ensuing tension was recorded (B). Compared to aorta from WT piglets, aorta from dF piglets had deceased constriction during incubation in PSS buffer, calcium free buffer with EGTA or PSS with ryanodine (C). Combined inhibition of ryanodine and IP3 receptors with both ryanodine (1 μM) and 2-APB (50 μM) reduced the tone of aorta from WT or CFTR-null piglets to approximate the tone of dF aorta. *P<0.05 versus WT, #P<0.05 versus buffer alone.