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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Pain. 2014 Jan 9;15(4):407–421. doi: 10.1016/j.jpain.2013.12.007

Figure 6.

Figure 6

Assessment of the effects of ceasing (+)-naltrexone on SNAP. Rats were tested for mechanical allodynia across a timecourse on both the ipsilateral (A) and contralateral (B) hindpaw. Rats that received (+)-naltrexone (6 mg/kg, s.c.) for 6 days beginning 28 days after surgery were significantly less allodynic than rats that received vehicle in both the ipsilateral (C) and contralateral (D) hindpaw. After stopping (+)-naltrexone administration on day 33, rats that were receiving (+)-naltrexone returned to pre-drug allodynia thresholds in both the ipsilateral (E) and contralateral (F) hindpaw. Data are presented as mean ± SEM and analyzed using a t-test on the AUCs, n=6 per group. *p<0.05 compared to all other groups.