Table 4. Population averaged responses (proportions), relative risks, and risk differences of the 12 antidepressants.
| BUP | CIT | DUL | ESC | FLU | FVX | MIL | MIR | PAR | REB | SER | VEN | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BUP | 0.57 (0.52,0.62) | 1.02 (0.90,1.16) | 1.09 (0.94,1.27) | 0.95 (0.85,1.05) | 1.07 (0.97,1.18) | 1.09 (0.94,1.26) | 1.10 (0.90,1.36) | 0.92 (0.82,1.03) | 1.04 (0.94,1.15) | 1.19 (1.02,1.42) | 0.97 (0.88,1.07) | 0.95 (0.87,1.05) |
| CIT | 0.01 (-0.06,0.08) | 0.56 (0.50,0.62) | 1.07 (0.91,1.25) | 0.93 (0.83,1.03) | 1.05 (0.94,1.16) | 1.07 (0.92,1.24) | 1.08 (0.87,1.34) | 0.90 (0.80,1.02) | 1.02 (0.91,1.14) | 1.17* (0.99,1.38) | 0.95 (0.84,1.06) | 0.94 (0.83,1.04) |
| DUL | 0.05 (-0.04,0.13) | 0.03 (-0.05,0.12) | 0.52 (0.46,0.60) | 0.87 (0.76,0.99) | 0.98 (0.86,1.12) | 1.00 (0.84,1.20) | 1.01 (0.80,1.28) | 0.85 (0.73,0.98) | 0.96 (0.83,1.09) | 1.09* (0.91,1.34) | 0.89* (0.77,1.03) | 0.88* (0.76,1.01) |
| ESC | -0.03 (-0.09,0.03) | -0.04 (-0.11,0.02) | -0.08 (-0.15,-0.01) | 0.60 (0.56,0.65) | 1.13 (1.04,1.23) | 1.15 (1.01,1.33) | 1.16 (0.95,1.43) | 0.97 (0.88,1.08) | 1.10 (1.01,1.20) | 1.26 (1.08,1.49) | 1.03 (0.94,1.13) | 1.01 (0.92,1.10) |
| FLU | 0.04 (-0.02,0.09) | 0.03 (-0.03,0.08) | -0.01 (-0.08,0.07) | 0.07 (0.02,0.12) | 0.53 (0.50,0.56) | 1.02 (0.90,1.16) | 1.03 (0.85,1.25) | 0.86 (0.79,0.94) | 0.97 (0.90,1.05) | 1.11* (0.96,1.30) | 0.91 (0.84,0.98) | 0.89 (0.83,0.96) |
| FVX | 0.05 (-0.03,0.12) | 0.03 (-0.05,0.11) | 0.00 (-0.09,0.09) | 0.08 (0.00,0.15) | 0.01 (-0.06,0.08) | 0.52 (0.46,0.59) | 1.01 (0.82,1.26) | 0.85 (0.74,0.97) | 0.96 (0.83,1.08) | 1.09* (0.91,1.33) | 0.89* (0.78,1.02) | 0.88 (0.76,1.00) |
| MIL | 0.05 (-0.06,0.16) | 0.04 (-0.08,0.15) | 0.01 (-0.12,0.12) | 0.08 (-0.03,0.19) | 0.01 (-0.09,0.11) | 0.01 (-0.11,0.11) | 0.52 (0.43,0.63) | 0.84 (0.68,1.02) | 0.95 (0.78,1.14) | 1.08* (0.85,1.38) | 0.88 (0.72,1.07) | 0.87 (0.71,1.05) |
| MIR | -0.05 (-0.12,0.02) | -0.06 (-0.13,0.01) | -0.09 (-0.18,-0.01) | -0.02 (-0.08,0.05) | -0.09 (-0.14,-0.03) | -0.09 (-0.17,-0.02) | -0.10 (-0.20,0.02) | 0.62 (0.57,0.67) | 1.13 (1.03,1.24) | 1.29 (1.10,1.54) | 1.05 (0.95,1.16) | 1.04 (0.94,1.14) |
| PAR | 0.02 (-0.03,0.08) | 0.01 (-0.05,0.07) | -0.02 (-0.09,0.05) | 0.06 (0.00,0.11) | -0.02 (-0.05,0.02) | -0.02 (-0.09,0.05) | -0.03 (-0.13,0.08) | 0.07 (0.02,0.13) | 0.55 (0.51,0.58) | 1.14* (0.99,1.35) | 0.93* (0.86,1.02) | 0.92 (0.84,1.00) |
| REB | 0.09 (0.01,0.17) | 0.08* (-0.01,0.16) | 0.05* (-0.05,0.14) | 0.12 (0.04,0.20) | 0.05* (-0.02,0.13) | 0.05* (-0.05,0.14) | 0.04* (-0.08,0.17) | 0.14 (0.06,0.22) | 0.07* (-0.01,0.15) | 0.48 (0.41,0.55) | 0.82 (0.69,0.95) | 0.80 (0.68,0.93) |
| SER | -0.02 (-0.08,0.04) | -0.03 (-0.10,0.04) | -0.06* (-0.14,0.02) | 0.02 (-0.04,0.07) | -0.06 (-0.10,-0.01) | -0.06* (-0.14,0.01) | -0.07 (-0.17,0.04) | 0.03 (-0.03,0.09) | -0.04* (-0.09,0.01) | -0.11 (-0.19,-0.03) | 0.59 (0.54,0.63) | 0.98 (0.90,1.07) |
| VEN | -0.03 (-0.08,0.03) | -0.04 (-0.11,0.03) | -0.07* (-0.15,0.01) | 0.01 (-0.05,0.06) | -0.07 (-0.11,-0.02) | -0.07 (-0.15,-0.00) | -0.08 (-0.18,0.03) | 0.02 (-0.04,0.08) | -0.05 (-0.10,-0.00) | -0.12 (-0.20,-0.04) | -0.01 (-0.06,0.04) | 0.60 (0.56,0.64) |
Drugs are reported in alphabetical order. Diagonal panels are the population averaged response rates (i.e., proportion of patients who had at least 50% reduction from the baseline score on HDRS); upper triangular and lower triangular panels are the relative risks (RRs) and risk differences (RDs) of the first drug in alphabetical order compared with the second drug in alphabetical order, respectively. Drugs with higher response rate are more effective; RRs larger than 1.0 or positive RDs favor the first drug in alphabetical order. To obtain comparisons in the opposite direction, reciprocals should be taken for RR and opposite sign should be used for RD. Statistically significant results are in bold and underlined. Comparisons statistically significant here but not in Cipriani et al6. or vice versa are noted with *. For all summaries, we report both the Bayesian posterior medians and the 95% credible intervals. BUR=bupropion, CIT=citalopram, DUL=duloxetine, ESC=escitalopram, FLU=fluoxetine, FVX=fluvoxamine (FVX), MIL=milnacipran, MIR=mirtazapine, PAR=paroxetine, REB=reboxetine, SER=sertraline, and VEN=venlafaxine.