Fig. 1.

CLP-induced rise in peritoneal macrophage migratory capacity is reduced by PD-1 gene deficiency. a Representative tracing of mouse peritoneal macrophage migration over time of cells derived from septic PD-1−/− mice as compared to cells from septic WT mice (48 h post-CLP). b At 24 h, CLP mice macrophages migrate further, but there is no difference in the absence of PD-1. However, at 48 h, CLP PD-1−/− mice had greatly reduced migratory distance when compared to CLP WT mouse cells, but again with no differences in the Sham groups. c Similar results were seen in motility. * p < 0.05 versus PD-1−/− CLP (n = 5-6 per group), determined by ANOVA followed by Tukey's test.