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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Dev Biol. 2013 Dec 3;389(1):39–49. doi: 10.1016/j.ydbio.2013.11.025

Fig. 2.

Fig. 2

Experimentally verified Notch signaling in neurogenic placodes. Notch1-RBPjk signaling negatively regulates neurogenesis and delamination in the trigeminal (V) and geniculate (VII) placodes. Activation or inhibition of NICD down- or up-regulates neurogenic factors in the olfactory (olf), trigeminal, and otic placodes, respectively. DAPT shown in brackets is a pharmacological antagonist for Notch signaling via inhibition of gamma-secretase. mmV & opV, maxillomandibular & ophthalmic trigeminal placodes. All neurogenic placodal regions (except the olfactory) are visualized by Sox10 in situ signals on an E9.5 mouse embryo.