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Experimentally verified BMP signaling in neurogenic placodes. BMP4/7-Bmpr1b signaling exerts positive roles in the epibranchial neurogenesis, while constitutively active (ca) Bmpr1b (ALK3) shows no effects on the otic placode, and a negative role in the olfactory placode neurogenesis or delamination. The inhibitory proteins PRDC, Follistatin, and Noggin repress the epibranchial neurogenesis, and Noggin also represses the olfactory neurogenesis.
