Table 1.
Body weight, liver weight and liver index of the experimental rats
| Parameters | CON | HFFD | HFFD + GSP | HFFD + MET | HFFD + GSP + MET | CON + GSP |
|---|---|---|---|---|---|---|
| Body wt | ||||||
| Initial (g) | 152.8 ± 11.2 | 154.2 ± 11.3 | 155.4 ± 10.5 | 156.8 ± 11.6 | 154.4 ± 11.9 | 153.6 ± 10.8 |
| Final (g) | 169.3 ± 14.3 | 220.5 ± 12.2a | 183.2 ± 10.3b | 192.3 ± 14.9b | 180.5 ± 13.6b | 170.2 ± 14.6b |
| Liver wt (g) | 7.19 ± 0.3 | 8.70 ± 0.2a | 7.67 ± 0.2b | 8.03 ± 0.6a,f | 7.37 ± 0.4b | 7.27 ± 0.3b,d |
| Liver index (%) | 4.24 ± 0.1 | 3.95 ± 0.2a | 4.19 ± 0.2b | 4.17 ± 0.3b | 4.08 ± 0.1b | 4.27 ± 0.2b |
CON control, HFFD high fat, fructose diet, HFFD + GSP high fat, fructose diet + grape seed proanthocyanidins, HFFD + MET high fat, fructose diet + metformin, HFFD + GSP + MET high fat, fructose diet + grape seed proanthocyanidins + metformin, CON + GSP control + grape seed proanthocyanidins
Liver index (%) = liver weight (g)/body weight (g) × 100
Values are means ± SD of six rats from each group. a = values significantly different from CON; b = values significantly different from HFFD; c = values significantly different from HFFD + GSP; d = values significantly different from HFFD + MET; e = values significantly different from HFFD + GSP + MET; f = values significantly different from CON + GSP. [One way ANOVA followed by Bonferroni test for multiple comparisons. Value that has p < 0.05 was considered statistically significant]