Fig. 4.

HMGB1 siRNA and RAGE siRNA decreased the cell viability of HCCLM3 cells. a Knockdown of HMGB1 or RAGE in HCCLM3 cells by specific gene-targeted HMGB1-siRNA and RAGE-siRNA was confirmed by qRT-PCR. Add a descriptive label of the figure here. b After incubating with HMGB1-siRNA (75 ng/ml), RAGE-siRNA (75 ng/ml), and rhHMGB1 (50 ng/ml) for 48 h, the results of MTT assay showed that knockdown of HMGB1 or RAGE decreased the cell viability of HCCLM3 cells (*P < 0.05, **P < 0.01). NC negative control with a nonsense siRNA sequence