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Phosphatidylcholine biosynthesis in A. tumefaciens. In the PC synthase pathway, the integral membrane protein Pcs condenses CDP-DAG and choline to PC. Choline is taken up via the ChoXWV transporter. In the PmtA pathway, a single peripheral phospholipid N-methyltransferase (PmtA) converts PE via three successive methylations to PC. PmtA is stimulated by the anionic lipid PG and inhibited by PC and SAH. CM, cytoplasmic membrane.
