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. 2014 Mar 26;8:23. doi: 10.3389/fncir.2014.00023

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Copyright © 2014 Liu, Wang and Cang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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On–Off overlap is disrupted in nAChR-β2 KOs, but not in ephrin-A KOs. (A) On (red) and Off (green) responses of a WT SC neuron, showing substantial On–Off overlap. Color scales represent evoked responses in spikes/s during the 500 ms duration of stimulus presentation. The calculated values of overlap ratio (O.R.) and correlation coefficient (C.C.) are listed at the upper right corner of the “Off” plot. (B) On and Off responses of an example neuron in ephrin-A DKO mice. (C) Responses of an example neuron in nAChR-β2 subunit knockout. (D) Comparison of On–Off overlap ratio between genotypes, with only β2 KOs showing a significant disruption comparing to the WT. (E) Comparison of On–Off correlation coefficient between genotypes. Panel D and E are box plots with ends of each plot representing 5th and 95th percentiles. **p < 0.01 and ***p < 0.001.