Table 3.

Comparisons of Clinical Periodontal Measurements [mean (SD)] Between Cases and Controls

	Unadjusted average (SD)		P-value for case vs. control
Characteristic	BRONJ (N=25)	Non-BRONJ (N=48)	Unadjusted Analysis	Adjusted Analysis 1†	Adjusted Analysis 2¶
Number of missing teeth*	7.8 (8.2)	3.1 (4.6)	0.002	0.011	0.004
Mean Plaque Index	0.40 (0.29)	0.55 (0.41)	0.13	0.064	0.41
Mean Gingival Index	0.54 (0.25)	0.58 (0.31)	0.62	0.47	0.84
Bleeding on Probing (%)	12.0 (15.4)	14.9 (12.8)	0.42	0.37	0.62
Mean full-mouth PD (mm)	2.07 (0.34)	2.11 (0.31)	0.60	0.40	0.81
Mean full-mouth CAL (mm)	2.18 (1.55)	1.56 (0.99)	0.047	0.11	0.016
% Sites PD 4–6 mm	5.0 (4.6)	4.8 (6.5)	0.87	0.76	0.70
% Sites CAL ≥3 mm	39.0 (35.9)	23.3 (25.3)	0.039	0.10	0.015

^*Out of 28, i.e., not counting 3rd molars. Teeth extracted shortly before BRONJ development are not counted as missing

^†Adjusted for age, sex, and smoking status (ever vs. never)

^¶Adjusted for age, sex, smoking status (ever vs. never), and number of BP infusions (analyses excludes six BRONJ cases who received 60 or more infusions)