Skip to main content
. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Curr Breast Cancer Rep. 2013 Oct 10;5(4):302–308. doi: 10.1007/s12609-013-0123-y

Figure 1.

Figure 1

The hypothalamic-pituitary-gonadal axis. The secretion of gonadotropin-releasing hormone (GnRH) from cells in the hypothalamus stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis and secretion from the pituitary gland. These in turn control follicular recruitment and estrogen (E2) production at the gonadal level. Feedback of sex steroids occurs at both the pituitary and hypothalamic levels. Antimüllerian hormone (AMH) derives from early stage developing follicles and is the best current marker of ovarian reserve. The studies that utilized AMH as an ovarian reserve marker did not show any benefit from ovarian suppression in protecting ovarian reserve against chemotherapy damage [41, 42].