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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jul 2;5(5):449–468. doi: 10.1002/wnan.1233

Figure 4.

Figure 4

Widely-used approaches to improving polymeric siRNA delivery include conjugation to PEG and targeting ligands (A) and introduction of disulfide bridges for controlled cytoplasmic release (B). Part A reprinted with permission from Christie, R. J.; Matsumoto, Y.; Miyata, K.; Nomoto, T.; Fukushima, S.; Osada, K.; Halnaut, J.; Pittella, F.; Kim, H. J.; Nishiyama, N.; Kataoka, K.: Targeted Polymeric Micelles for siRNA Treatment of Experimental Cancer by Intravenous Injection. ACS Nano 2012, 6, 5174–5189.106 Copyright (2012) American Chemical Society. Part B reprinted from Journal of Controlled Release, 150/2, van der Aa et al, Optimization of poly(amido amine)s as vectors for siRNA delivery, 177–186,112 Copyright (2011), with permission from Elsevier.