Table 1.

Reasons for initial and terminal screen failure.

Failure Reason	Initial screen failure, n (%)	Rescreened after initial failure
		Second failure, n (%)	Exclusion resolved for inclusion, n (%)	Total rescreened, n (%)
Total number of participants	176 (100)	4 (2.2)	55 (31)	59 (33.5)
Exacerbation within 30 days	32 (18.2)	1 (25)	16 (29.1)
< 2 exacerbations in prior 3 years	22 (12.5)		6 (10.9)
Other medical condition	19 (10.8)	1 (25)	5 (9.1)
Abnormal lab value	17 (9.7)	1 (25)	7 (12.7)
Inconclusive for / Not RRMS	13 (7.4)		1 (1.8)
Unable to have MRI/Gad sensitivity	7 (4.0)		2 (3.6)
EDSS > 5.5	2 (1.1)	1 (25)
Other reason*	64 (36.3)		18 (32.7)

^*Other non-medical reasons, including: site error, exceeding screening window, and participant decision