Figure 5.

A role for ICP27 in protection against HSV challenge following immunization. A DNA vaccine against ICP27 was used to immunize mice prior to challenge with HSV-2 in intravaginal (A, B) and intranasal (C) models of infection. A) Virus shedding was detected by viral plaque assays at days 1 (closed circles) and 4 (closed squares) post infection. B) Mean clinical score for ICP27 vaccinated (open squares) and naive (crosses) groups at each day for fourteen days post-infection. C) Mean clinical scores for ICP27 vaccinated (closed triangle), mock vaccinated (open rhombus) and naive (closed squares) groups at each day for fourteen days post-infection.