Table 1.

Target genes of tricho-rhino-phalangeal syndrome (Trps) 1, interaction and function of Trps1, the tissues where the interaction with Trps1 takes place, and the consequences of the interaction.

Target Genes	Interaction/function of Trps1	Tissues	Consequences of Trps1 deficiency	References
PTHrP	Direct promotor binding/repressive	Developing growth plate	Enlongated proliferative zone	[33]
Stat3	Direct promotor binding/repressive	Developing growth plate	Apoptosis resistance due to elevated Bcl-2	[14]
Sox9	Direct promotor binding/repressive	Developing vibrissae follicles	Increased cell proliferation	[23]
Wnt inhibitors	Direct promotor binding/activative	Developing vibrissae follicles	Enhanced Wnt signaling	[12]
Anti-oxidants	Unknown/repressive	Prostate cancer cells	Apoptosis resistance	[3,47,50]
TGF-β/Smad3 pathway	Unknown/repressive	Developing kidneys	Increased apoptosis	[38,39]