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. 2013 Jul 2;2(3):506–544. doi: 10.3390/cells2030506

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 9. — Single rosette-like structure assembly in mitosis. (A) Shows a rosette-like structure where SACis active and no microtubule is present or attached; (B) Same as in Panel A, showing the rosette-shape in top view; (C) Shows a rosette-like structure attached to a microtubule and including the Ska complex, where the Spindle Assembly Checkpoint (SAC) switched off; (D) Same as Panel A, showing the rosette-shape in top view similar to Panel B, while SAC is inactive. The distance between two nucleosomes is 14 nm, and consequently, the diameter of the rosette-shape and microtubule is 25 nm. The rosette-structure and the Ska-complex are 60 nm apart. The attached, as well as the unattached kinetochore took about one hour to simulate.