Figure 1.

Schematic representation of 5′- and 3′-end structures of the human NKCC1 gene identified by RACE. The genomic organization of the human NKCC1 gene (full-length isoform NKCC1a) is shown at the top of the figure, along with horizontal arrows indicating transcriptional orientation. The continuous line indicates genomic sequence, on which known exons of NKCC1 are shown as rectangles and numbered. The newly identified exons 2a and 4a are shown as small rectangles. The exons contained within the 5′ and 3′ RACE products are indicated as boxes linked by a solid line. The one alternative first exon and the 10 alternative termination exons (NKCC1 exon 2a, 4a, and 27) were detected by RACE.