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. 2014 Apr 2;34(14):4929–4940. doi: 10.1523/JNEUROSCI.1423-13.2014

Figure 7.

Figure 7.

Expression of NKCC1 transcripts in the DLPFC of patients with schizophrenia and normal controls. We examined the association of 10 NKCC1 SNPs with the mRNA expression levels of NKCC1 splice variants. All data were covaried by age at death, pH, RIN, and sex. The mRNA expression of NKCC1a (1–27) and NKCC1b (1–27 (Δ21)) was significantly associated with rs12189448: carriers of the minor (C) allele (NKCC1a: N = 82; NKCC1b: N = 81) had significantly lower expression of both transcripts compared with individuals homozygous for the major (A) allele (NKCC1a: N = 12; NKCC1b: N = 12) (*). Furthermore, rs3087889 was significantly associated with the expression of NKCC1b (1–27 (Δ21)) in a dose-dependent fashion. In particular, individuals homozygous for the minor allele (A) at rs3087889 (N = 15) had significantly lower expression than those homozygous for the major allele (T) (N = 37) (p < 0.01) (**). Genotype and allele frequencies by race for rs3087889 are seen in 6.