Figure 8.

NKCC1 rs3087889 predicts prefrontal inefficiency in healthy controls during a working memory task. Healthy individuals carrying the minor allele (A) of NKCC1 rs3087889 that was associated with mRNA expression and risk for schizophrenia showed greater left DLPFC activation during the N-back working memory task assayed by BOLD fMRI. We compared 186 NKCC1 T/T subjects against 127 NKCC1 A carriers who otherwise did not differ in age, gender, WAIS-IQ, N-back reaction time, and N-back performance (p > 0.05). We corrected BOLD fMRI results for a small volume and familywise error (SVC, FWE): p < 0.05 given our prior hypothesis of activation differences in the prefrontal cortex (efficiency) and location of postmortem assays. For illustrative purposes, we display results here at p < 0.01 and in arbitrary units (au).