Table 5.
Healthy controls | SCZ | Family | |
---|---|---|---|
Verbal memory | 0.901 (N = 409) | 0.519 (N = 302) | 0.041 (N = 91) |
N-back | 0.006* (N = 369) | 0.674 (N = 181) | 0.061 (N = 60) |
Visual memory | 0.366 (N = 271) | 0.827 (N = 298) | 0.004* (N = 91) |
Processing speed | 0.119 (N = 408) | 0.671 (N = 302) | 0.018 (N = 90) |
Card sorting | 0.155 (N = 399) | 0.507 (N = 295) | 0.028 (N = 89) |
Digit span | 0.350 (N = 288) | 0.838 (N = 301) | 0.035 (N = 91) |
g | 0.030 (N = 391) | 0.548 (N = 299) | 0.678 (N = 89) |
aNKCC1 rs3087889 A allele was associated with working memory (N = 369) and g (N = 391) in healthy subjects. Although not associated with cognitive measures in schizophrenic subjects per se, family-based association showed that this SNP associated with between-sibling differences in most factors to some extent.
*p values survive minimal correction for number of factor scores tabulated (n = 7, p < 0.007); however, they would not survive a more rigorous correction for number of scores and grouping variables (n = 21, p < 0.002).