. 2014 Jan 30;116(7):715–723. doi: 10.1152/japplphysiol.01235.2013

Table 1.

Arterial blood gases and minute ventilation in controls, with acetazolamide iv, acetazolamide po, inhaled acetazolamide, methazolamide iv, and N-methyl-acetazolamide iv during normoxia and hypoxia

	n	Normoxia 1 h	Hypoxia 1st h	Hypoxia 2nd h
Pa_O₂, Torr
Series 1
Controls	7	93 ± 3	36 ± 1^*	36 ± 3^*
ACZ iv	7	109 ± 5^†	38 ± 2^*	39 ± 2^*
ACZ po	7	108 ± 4^†	37 ± 2^*	37 ± 1^*
ACZ inhaled	7	101 ± 7^†	39 ± 3^*	37 ± 3^*
Series 2
Controls	9	95 ± 4	35 ± 1^*	36 ± 2^*
ACZ iv	8	108 ± 4^†	40 ± 3^*	40 ± 1^*
MTZ iv	6	109 ± 4^†	38 ± 3^*	38 ± 2^*
NMA iv	6	95 ± 9	37 ± 2^*	38 ± 1^*
Pa_CO₂, Torr
Series 1
Controls	7	37 ± 3	29 ± 3^*	28 ± 4^*
ACZ iv	7	34 ± 2	28 ± 3^*	27 ± 2^*
ACZ po	7	32 ± 2^†	28 ± 3	26 ± 2^*
ACZ inhaled	7	36 ± 2	26 ± 2^*	25 ± 2^*
Series 2
Controls	9	36 ± 2	29 ± 2^*	26 ± 3^*
ACZ iv	8	33 ± 2^†	28 ± 1^*	25 ± 1^*
MTZ iv	6	33 ± 3	26 ± 1^*	26 ± 2^*
NMA iv	6	37 ± 2	27 ± 2^*	27 ± 2^*
V̇e, l/min
Series 1
Controls	7	3.5 ± 1.2	5.6 ± 1.7^*	5.4 ± 1.6^*
ACZ iv	7	3.9 ± 0.7	6.4 ± 1.4^*	7.1 ± 1.3^*
ACZ po	7	4.9 ± 0.8	6.6 ± 1.1	6.5 ± 0.7
ACZ inhaled	7	3.1 ± 0.7	5.3 ± 1.2^*	5.6 ± 1.2^*
Series 2
Controls	9	2.8 ± 0.6	4.8 ± 0.6^*	4.8 ± 0.8^*
ACZ iv	8	4.0 ± 1.0	6.2 ± 1.5^*	6.5 ± 1.5^*
MTZ iv	6	4.3 ± 1.5	6.7 ± 1.3^*^†	6.7 ± 0.9^*
NMA iv	6	3.4 ± 1.2	5.5 ± 1.8^*	5.6 ± 1.9^*

Values are means ± SD; n, no. of experiments.

Pa_O₂, arterial oxygen tension; Pa_CO₂, arterial carbon dioxide tension; V̇e, expiratory minute ventilation; ACZ, acetazolamide; MTZ, methazolamide; NMA, N-methyl-acetazolamide; iv, intravenous; po, per os.

Significant differences (P < 0.05) vs.

normoxia and

^†

controls at equal time points.