Table 1.
Major ventilatory parameters of 7 dogs with the GRMD mutation and 5 normal control dogs included in the doxapram study
| Animal ID | Dystrophin, ± | Age, months | Weight, kg | Ventilation, ml·kg−1·min−1 (baseline) | Ventilation, ml·kg−1·min−1 (1 mg/kg doxapram) | Tidal volume, ml/kg (baseline) | Tidal volume, ml/kg (1 mg/kg doxapram) | Respiratory rate, breaths/min (baseline) | Respiratory rate, breaths/min (1 mg/kg doxapram) |
|---|---|---|---|---|---|---|---|---|---|
| g892 | − | 10 | 16.6 | 17.5 | 246.5 | 3.5 | 12.1 | 5 | 25 |
| g092 | − | 13 | 13 | 142 | 375.3 | 10.9 | 22.1 | 13 | 17 |
| g124 | − | 6 | 9.8 | 58.2 | 189.8 | 5.8 | 9.7 | 10 | 20 |
| g547 | − | 17 | 17.3 | 57.5 | 372.3 | 8.2 | 18.6 | 7 | 23 |
| g033 | − | 16 | 19.3 | 116.5 | 408 | 9 | 17.3 | 13 | 25 |
| g566 | − | 16 | 13.8 | 38.8 | 333.8 | 7.8 | 19.6 | 5 | 17 |
| g890 | − | 17 | 20 | 90.8 | 308.1 | 5.7 | 10.6 | 16 | 29 |
| n290 | + | 7 | 21.5 | 109.8 | 304.4 | 11 | 23.3 | 10 | 16 |
| n559 | + | 7 | 20.3 | 83.1 | 463.3 | 13.8 | 31.3 | 6 | 15 |
| n530 | + | 9 | 23 | 82.8 | 346.4 | 10.3 | 22.6 | 8 | 16 |
| n256 | + | 13 | 27.8 | 135.1 | 330.9 | 11.3 | 21.6 | 12 | 19 |
| n016 | + | 7 | 20 | 115 | 576.3 | 10.5 | 24 | 10 | 25 |