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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Med. 2014 Jan 26;20(2):152–158. doi: 10.1038/nm.3458

Table 1.

Structures and activities of representative spectinamides.

graphic file with name nihms-551113-t0001.jpg

Abbreviations: MIC, minimum inhibitory concentration; Spec, spectinomycin; nd, not determined.

1,2MIC activity against M. tuberculosis H37Rv and Rv1258c Tap pump knockout strains (determined using method 1); 3translation inhibition against M. smegmatis (mycobacterial) ribosomes;4,5 bacterial ribosomes mutated to contain the mitochondrial (mitohybrid), and cytosolic (cytohybrid) helix 34 sequences;6 rabbit reticulocyte ribosomes representing native eukaryotic ribosomes;7 mammalian cytotoxicity determined against the Vero and J774 cell lines.