Table 3.
Compound | MIC90 (μg/ml)2 | MIC50 (μg/ml)2 | MIC range (μg/ml)3 |
---|---|---|---|
1329 | 3.8 | 2.3 | 1.6 – 7.5 |
1445 | 3.8 | 1.6 | 0.8 – 3.8 |
1544 | 1.8 | 1.6 | 0.8 – 1.8 |
1599 | 1.9 | 0.8 | 0.3 – 1.9 |
The panel consisted of 19 MDR and 5 XDR strains; MDR strains were resistant to isoniazid, rifampicin, and at least 2 other antitubercular antibiotics, whereas XDR strains were resistant to isoniazid, rifampicin, ofloxacin, and kanamycin. All strains were resistant to at least 4 different classes of antimycobacterial drugs; this included 8 streptomycin- and 7 kanamycin-resistant strains.
MIC90 and MIC50 refer to the MIC value at which 90% and 50% of the strains are susceptible.
The range refers to MIC values across the whole MDR/XDR panel of 24 strains. See Supplementary Table 3 for details. MICs were determined using methods 1 and 2.