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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Med. 2014 Jan 26;20(2):152–158. doi: 10.1038/nm.3458

Table 3.

Activity of spectinamides against multiple isolates of MDR- and XDR-tuberculosis1 (n= 24)

Compound MIC90 (μg/ml)2 MIC50 (μg/ml)2 MIC range (μg/ml)3
1329 3.8 2.3 1.6 – 7.5
1445 3.8 1.6 0.8 – 3.8
1544 1.8 1.6 0.8 – 1.8
1599 1.9 0.8 0.3 – 1.9
1

The panel consisted of 19 MDR and 5 XDR strains; MDR strains were resistant to isoniazid, rifampicin, and at least 2 other antitubercular antibiotics, whereas XDR strains were resistant to isoniazid, rifampicin, ofloxacin, and kanamycin. All strains were resistant to at least 4 different classes of antimycobacterial drugs; this included 8 streptomycin- and 7 kanamycin-resistant strains.

2

MIC90 and MIC50 refer to the MIC value at which 90% and 50% of the strains are susceptible.

3

The range refers to MIC values across the whole MDR/XDR panel of 24 strains. See Supplementary Table 3 for details. MICs were determined using methods 1 and 2.